HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromothioanisole → (2r)-4-Benzyl-2-methyl-1-(2-methylthiophenyl) piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromothioanisole | HCID 88166 | — |
| Reactant | (R)-1-Benzyl-3-methylpiperazine | HCID 6923226 | — |
| Product | (2r)-4-Benzyl-2-methyl-1-(2-methylthiophenyl) piperazine | HCID 69410672 | 26% |
Reaction Steps
(2R)-4-Benzyl-2-methyl-1-(2-methylthiophenyl) piperazine was prepared in 26% yield from ortho-bromothioanisole and (R)-3-methyl-1-benzylpiperazine in a manner similar to Preparation 1A. LRMS (ESI+): 223.2 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291619B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-a984f627ac98408494605a929392453b |
| Source note | uspto-grants-2007_11 |