N-(2-Cyanophenyl)piperazine → HCID 178420455, compound

Participants

Reaction Steps

A solution of 4-(2-cyano-phenyl)-piperazine (1.7 g, 9.0 mmol, 1.0 eq) in azidotributyltin (5.0 g, 15 mmol, 1.5 eq.) was stirred at 80° C. for about 5 days. Purification by SCX (10 g) ion exchange chromatography afforded crude 4-(2-tetrazole-5-yl-phenyl)-piperazine. LRMS (ESI+): 231.0 (M+1).

Provenance & Evidence