HCID 17952254, compound → HCID 69410731, compound

Participants

Reaction Steps

4-(2-Pyrrolidin-1-ylmethyl-phenyl)-piperazine-1-carboxylic acid t-butyl ester was deprotected and then the resulting amine hydrochloride (0.10 gm, 0.30 mmol) was coupled with lithium 2-[(2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-isoquinolin-3-ylmethyl)-(2-methoxy-ethyl)-amino]-3-(4-chloro-phenyl)-propionate (0.23 gm, 0.45 mmol). The mixture was chromatographed to obtain the crude coupled product [MS (m/z, ES+): 730.4], which was deprotected to give about 0.068 g of the final compound as brown solids. MS (m/z, ES+): 630.3

Provenance & Evidence