3-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole → 1-{[5-(3,5-Difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-2-ethyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 159288Notes

Reaction equation

HRID 159288 reaction equation
[CH2:1]([CH3:2])[c:3]1[nH:4][c:5]2[cH:6][cH:7][c:8]([C:16]#[N:17])[c:9]([C:12]([F:13])([F:14])[F:15])[c:10]2[cH:11]1.[Cl:18][CH2:19][c:20]1[n:21][o:22][c:23](-[c:25]2[cH:26][c:27]([F:32])[cH:28][c:29]([F:31])[cH:30]2)[n:24]1>>[CH2:1]([CH3:2])[c:3]1[n:4]([CH2:19][c:20]2[n:21][o:22][c:23](-[c:25]3[cH:26][c:27]([F:32])[cH:28][c:29]([F:31])[cH:30]3)[n:24]2)[c:5]2[cH:6][cH:7][c:8]([C:16]#[N:17])[c:9]([C:12]([F:13])([F:14])[F:15])[c:10]2[cH:11]1

Participants

3

Reactant 2

HCID 431202093-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazoleHCID 674038192-ethyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 674059631-{[5-(3,5-Difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-2-ethyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Sources & evidence

ORD record
ord-6328b9fd36f44855b89833aa33ad2596
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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