HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → tert-Butyl 4-cyano-4-(3-methoxyphenyl)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (3-Methoxyphenyl)acetonitrile | HCID 88310 | — |
| Reactant | N-BOC-N,N-Bis(2-chloroethyl)amine | HCID 11230235 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | tert-Butyl 4-cyano-4-(3-methoxyphenyl)piperidine-1-carboxylate | HCID 49760266 | 87.9% |
Reaction Steps
This compound is prepared by the procedure described in step A of preparation 1.8, from 16.3 g of sodium hydride at a concentration of 60% in oil in 400 ml of DMSO, 30 g of 3-methoxyphenylacetonitrile in 150 ml of THF and 47 g of tert-butyl bis(2-chloroethyl)carbamate in 100 ml of DMSO. This gives 54 g of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07294628B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-dca56bda4c174bc0b594391efec3d722 |
| Source note | uspto-grants-2007_11 |