HCID 10043323, compound → HCID 10383107, compound

HRID 1592890Notes

Reaction equation

HRID 1592890 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)=[CH:11][N:10]([C:19]3[CH:24]=[CH:23][C:22](=[O:25])[NH:21][N:20]=3)[N:9]=2)=[CH:4][CH:3]=1.[NH2:26]C1C=C(C2C(C3C=CC(F)=CC=3)=NN(C3C=CC(=O)NN=3)C=2)C=CN=1>>[NH2:26][C:23]1[C:22](=[O:25])[NH:21][N:20]=[C:19]([N:10]2[CH:11]=[C:12]([C:13]3[CH:14]=[CH:15][N:16]=[CH:17][CH:18]=3)[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[N:9]2)[CH:24]=1

Participants

3

Reactant 2

HCID 10043323HCID 10043323, compoundHCID 10404570HCID 10404570, compound

Product 1

HCID 10383107HCID 10383107, compoundYield 40%

Procedure

The reaction was carried out in the same manner as in Example 4 except for using 213 mg (0.64 mmol) of 3-(4-fluorophenyl)-1-(1,6-dihydro-6-oxopyridazin-3-yl)-4-(pyridin-4-yl)-1H-pyrazole obtained in Example 1-4) in place of 4-(2-aminopyridin-4-yl)-3-(4-fluorophenyl)-1-(1,6-dihydro-6-oxopyridazin-3-yl)-1H-pyrazole to obtain 90.3 mg of the title compound as a white powder. (Yield: 40%)

Sources & evidence

ORD record
ord-5221cee0325740e28e59cc79a7430fc7
Source dataset
uspto-grants-2007_11
Patent number
US07294625B2

Reaction notes

Loading…