2-(2-t-Butoxycarbonylaminopyridin-4-yl)-1-(3,4-difluorophenyl)-3-dimethylamino-2-propen-1-one → HCID 178452642, compound

HRID 1592893Notes

Reaction equation

HRID 1592893 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([C:15](=[CH:26][N:27](C)C)[C:16]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[C:20]([F:25])[CH:19]=2)=O)[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC([NH:37]C1C=C(C(=CN(C)C)C(C2C=CC(F)=CC=2)=O)C=CN=1)=O)(C)(C)C>>[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([C:15]2[C:16]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[C:20]([F:25])[CH:19]=3)=[N:37][NH:27][CH:26]=2)[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 694156492-(2-t-Butoxycarbonylaminopyridin-4-yl)-1-(3,4-difluorophenyl)-3-dimethylamino-2-propen-1-oneHCID 694159932-(2-t-Butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-(4-fluorophenyl)-2-propen-1-one

Product 1

HCID 178452642HCID 178452642, compoundYield 87%

Procedure

The reaction was carried out in the same manner as in Example 2-2) except for using 9.28 g (23.0 mmol) of 2-(2-t-butoxycarbonylaminopyridin-4-yl)-1-(3,4-difluorophenyl)-3-dimethylamino-2-propen-1-one obtained in Example 24-2) in place of 2-(2-t-butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-(4-fluorophenyl)-2-propen-1-one to obtain 7.41 g of the title compound as a white powder. (Yield: 87%)

Sources & evidence

ORD record
ord-f717f0523a064af49cf486b49eb036b9
Source dataset
uspto-grants-2007_11
Patent number
US07294625B2

Reaction notes

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