2,2,2-Trifluoroethyl trifluoromethanesulfonate → HCID 86760569, compound

HRID 1592895Notes

Reaction equation

HRID 1592895 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([C:15]2[C:16]([C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=3)=[N:17][N:18]([C:20]3[N:21]=[N:22][C:23]([Cl:26])=[CH:24][CH:25]=3)[CH:19]=2)[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].O([CH2:42][C:43]([F:46])([F:45])[F:44])S(C(F)(F)F)(=O)=O>>[C:1]([O:5][C:6]([N:8]([CH2:42][C:43]([F:46])([F:45])[F:44])[C:9]1[CH:14]=[C:13]([C:15]2[C:16]([C:27]3[CH:28]=[CH:29][C:30]([F:33])=[CH:31][CH:32]=3)=[N:17][N:18]([C:20]3[N:21]=[N:22][C:23]([Cl:26])=[CH:24][CH:25]=3)[CH:19]=2)[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 23080626HCID 23080626, compound

Product 1

HCID 86760569HCID 86760569, compoundYield 52.4%

Procedure

The reaction was carried out in the same manner as in Example 3-1) except for using 5.60 g (12.0 mmol) of 4-(2-t-butoxycarbonylaminopyridin-4-yl)-1-(6-chloropyridazin-3-yl)-3-(4-fluorophenyl)-1H-pyrazole obtained by the same reaction as in Example 2-3), and using 4.18 g (18.0 mmol) of 2,2,2-trifluoroethyl triflate in place of methyl iodide to obtain 3.45 g of the title compound as a pale grayish white powder. (Yield: 52%)

Workup

  1. customobtained by the same reaction as in Example 2-3), and

Sources & evidence

ORD record
ord-8839668833844592b61d45fa9bc1bc1d
Source dataset
uspto-grants-2007_11
Patent number
US07294625B2

Reaction notes

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