HCID 23080636, compound → HCID 10251652, compound

HRID 1592900Notes

Reaction equation

C(OC([NH:8][C:9]1[CH:14]=[C:13]([C:15]2[C:16]([C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:37])[F:36])[CH:30]=3)=[N:17][N:18]([C:20]3[CH:21]=[CH:22][C:23]4[N:24]([CH:26]=[N:27][N:28]=4)[N:25]=3)[CH:19]=2)[CH:12]=[CH:11][N:10]=1)=O)(C)(C)C.C(OC(NC1C=C(C2C(C3C=CC=CC=3)=NN(C3C=CC4N(C=NN=4)N=3)C=2)C=CN=1)=O)(C)(C)C>>[NH2:8][C:9]1[CH:14]=[C:13]([C:15]2[C:16]([C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:37])[F:36])[CH:30]=3)=[N:17][N:18]([C:20]3[CH:21]=[CH:22][C:23]4[N:24]([CH:26]=[N:27][N:28]=4)[N:25]=3)[CH:19]=2)[CH:12]=[CH:11][N:10]=1

Participants

Reactant 2

HCID 23080636HCID 23080636, compound

HCID 69413637HCID 69413637, compound

Product 1

HCID 10251652HCID 10251652, compoundYield 66%

Procedure

The reaction was carried out in the same manner as in Example 37-2) except for using 2.35 g (4.50 mmol) of 4-(2-t-butoxycarbonylaminopyridin-4-yl)-1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-3-(3-trifluoromethylphenyl)-1H-pyrazole obtained in Example 41-1) in place of 4-(2-t-butoxycarbonylaminopyridin-4-yl)-3-phenyl-1-([1,2,4]triazolo[4,3-b]-pyridazin-6-yl)-1H-pyrazole to obtain 1.25 g of the title compound as a white powder. (Yield: 66%)

Sources & evidence

ORD record: ord-e795aa8fee1742b7980b106ff1b3e9d2
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07294625B2

Reaction notes

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