HCID 69413637, compound → HCID 10044778, compound

HRID 1592901Notes

Reaction equation

C(OC(NC1C=C(C2C(C3C=CC=CC=3[F:35])=NN(C3C=CC4N(C=NN=4)N=3)C=2)C=CN=1)=O)(C)(C)C.C(OC([NH:43][C:44]1[CH:49]=[C:48]([C:50]2[C:51]([C:64]3[CH:69]=[CH:68][CH:67]=[CH:66][CH:65]=3)=[N:52][N:53]([C:55]3[CH:56]=[CH:57][C:58]4[N:59]([CH:61]=[N:62][N:63]=4)[N:60]=3)[CH:54]=2)[CH:47]=[CH:46][N:45]=1)=O)(C)(C)C>>[NH2:43][C:44]1[CH:49]=[C:48]([C:50]2[C:51]([C:64]3[CH:69]=[CH:68][CH:67]=[C:66]([F:35])[CH:65]=3)=[N:52][N:53]([C:55]3[CH:56]=[CH:57][C:58]4[N:59]([CH:61]=[N:62][N:63]=4)[N:60]=3)[CH:54]=2)[CH:47]=[CH:46][N:45]=1

Participants

Reactant 2

HCID 69413637HCID 69413637, compound

HCID 69416767HCID 69416767, compound

Product 1

HCID 10044778HCID 10044778, compoundYield 86%

Procedure

The reaction was carried out in the same manner as in Example 37-2) except for using 4.00 g (8.47 mmol) of 4-(2-t-butoxycarbonylaminopyridin-4-yl)-3-(2-fluorophenyl)-1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazole obtained in Example 42-1) in place of 4-(2-t-butoxycarbonylaminopyridin-4-yl)-3-phenyl-1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazole to obtain 2.71 g of the title compound as a pale beige powder. (Yield: 86%)

Sources & evidence

ORD record: ord-75a12e8f7b6643b38e9f9d7e38f4a69c
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07294625B2

Reaction notes

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