Cyclopropanecarbonyl chloride → HCID 69418632, compound

Participants

Reaction Steps

The reaction was carried out in the same manner as in Example 9 except for using 100 mg (0.26 mmol) of 3-(4-fluorophenyl)-4-(2-methylaminopyridin-4-yl)-1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazole obtained in Example 13-2) in place of 4-(2-aminopyridin-4-yl)-3-(4-fluorophenyl)-1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazole, and using 81.2 mg (0.78 mmol) of cyclopropylcarbonyl chloride in place of acetic anhydride to obtain 93.8 mg of the title compound as a pale yellow-powder. (Yield: 80%)

Provenance & Evidence