Cyclopentanecarbonyl chloride → HCID 10073331, compound

HRID 1592904Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[C:9]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)=[N:10][N:11]([C:13]3[CH:14]=[CH:15][C:16]4[N:17]([CH:19]=[N:20][N:21]=4)[N:18]=3)[CH:12]=2)[CH:5]=[CH:4][N:3]=1.[CH:29]1([C:34](Cl)=[O:35])[CH2:33][CH2:32][CH2:31][CH2:30]1>>[CH:29]1([C:34]([NH:1][C:2]2[CH:7]=[C:6]([C:8]3[C:9]([C:22]4[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=4)=[N:10][N:11]([C:13]4[CH:14]=[CH:15][C:16]5[N:17]([CH:19]=[N:20][N:21]=5)[N:18]=4)[CH:12]=3)[CH:5]=[CH:4][N:3]=2)=[O:35])[CH2:33][CH2:32][CH2:31][CH2:30]1

Participants

Reactant 2

HCID 78284Cyclopentanecarbonyl chloride

HCID 9976519HCID 9976519, compound

Product 1

HCID 10073331HCID 10073331, compoundYield 9%

Procedure

The reaction was carried out in the same manner as in Example 9 except for using 2.00 g (5.37 mmol) of 4-(2-aminopyridin-4-yl)-3-(4-fluorophenyl)-1-([1,2,4]triazolo-[4,3-b]pyridazin-6-yl)-1H-pyrazole obtained by the same reaction as in Example 8-2), and using 1.07 g (8.06 mmol) of cyclopentylcarbonyl chloride in place of acetic anhydride to obtain 219 mg of the title compound as a white powder. (Yield: 9%)

Workup

customobtained by the same reaction as in Example 8-2), and

Sources & evidence

ORD record: ord-9d0bce45eb6d460b9ba05769042d959f
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07294625B2

Reaction notes

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