HCID 69413637, compound → HCID 10048870, compound

HRID 1592905Notes

Reaction equation

C(OC([NH:8][C:9]1[CH:14]=[C:13]([C:15]2[C:16]([C:33]3[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=3)=[N:17][N:18]([C:20]3[CH:21]=[CH:22][C:23]4[N:24]([C:26]([C:29]([F:32])([F:31])[F:30])=[N:27][N:28]=4)[N:25]=3)[CH:19]=2)[CH:12]=[CH:11][N:10]=1)=O)(C)(C)C.C(OC(NC1C=C(C2C(C3C=CC=CC=3)=NN(C3C=CC4N(C=NN=4)N=3)C=2)C=CN=1)=O)(C)(C)C>>[NH2:8][C:9]1[CH:14]=[C:13]([C:15]2[C:16]([C:33]3[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=3)=[N:17][N:18]([C:20]3[CH:21]=[CH:22][C:23]4[N:24]([C:26]([C:29]([F:31])([F:30])[F:32])=[N:27][N:28]=4)[N:25]=3)[CH:19]=2)[CH:12]=[CH:11][N:10]=1

Participants

Reactant 2

HCID 69413637HCID 69413637, compound

HCID 69414504HCID 69414504, compound

Product 1

HCID 10048870HCID 10048870, compoundYield 71%

Procedure

The reaction was carried out in the same manner as in Example 37-2) except for using 200 mg (0.37 mmol) of 4-(2-t-butoxycarbonylaminopyridin-4-yl)-3-(4-fluorophenyl)-1-(3-trifluoromethyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazole obtained in Example 47-1) in place of 4-(2-t-butoxycarbonylaminopyridin-4-yl)-3-phenyl-1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazole to obtain 115 mg of the title compound as a beige powder. (Yield: 71%)

Sources & evidence

ORD record: ord-db499bea53424a1490d17f38fadb6e3c
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07294625B2

Reaction notes

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