HCID 69413637, compound → HCID 10407872, compound

HRID 1592906Notes

Reaction equation

[NH2:1][C:2]1[N:6]2[N:7]=[C:8]([N:11]3[CH:15]=[C:14]([C:16]4[CH:21]=[CH:20][N:19]=[C:18]([NH:22]C(OC(C)(C)C)=O)[CH:17]=4)[C:13]([C:30]4[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=4)=[N:12]3)[CH:9]=[CH:10][C:5]2=[N:4][N:3]=1.C(OC(NC1C=C(C2C(C3C=CC=CC=3)=NN(C3C=CC4N(C=NN=4)N=3)C=2)C=CN=1)=O)(C)(C)C>>[NH2:22][C:18]1[CH:17]=[C:16]([C:14]2[C:13]([C:30]3[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=3)=[N:12][N:11]([C:8]3[CH:9]=[CH:10][C:5]4[N:6]([C:2]([NH2:1])=[N:3][N:4]=4)[N:7]=3)[CH:15]=2)[CH:21]=[CH:20][N:19]=1

Participants

Reactant 2

HCID 69413637HCID 69413637, compound

HCID 69414029HCID 69414029, compound

Product 1

HCID 10407872HCID 10407872, compoundYield 57%

Procedure

The reaction was carried out in the same manner as in Example 37-2) except for using 40.0 mg (0.082 mmol) of 1-(3-amino-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2-t-butoxycarbonylaminopyridin-4-yl)-3-(4-fluorophenyl)-1H-pyrazole obtained in Example 48-1) in place of 4-(2-t-butoxycarbonylaminopyridin-4-yl)-3-phenyl-1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazole to obtain 18.0 mg of the title compound as a yellow powder. (Yield: 57%)

Sources & evidence

ORD record: ord-1ff532858d9542de9f45d83f072e648a
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07294625B2

Reaction notes

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