HCID 9973892, compound → HCID 10020768, compound

HRID 1592907Notes

Reaction equation

HRID 1592907 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[C:9]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[N:10][N:11]([C:13]3[CH:18]=[CH:17][C:16](=[O:19])[NH:15][N:14]=3)[CH:12]=2)[CH:5]=[CH:4][N:3]=1.NC1C=C(C2C(C3C=CC=CC=3)=NN(C3C=CC(=O)NN=3)C=2)C=CN=1>>[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[C:9]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[N:10][N:11]([C:13]3[CH2:18][CH2:17][C:16](=[O:19])[NH:15][N:14]=3)[CH:12]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 9973892HCID 9973892, compoundHCID 10020638HCID 10020638, compound

Product 1

HCID 10020768HCID 10020768, compoundYield 69%

Procedure

The reaction was carried out in the same manner as in Example 49 except for using 300 mg (0.86 mmol) of 4-(2-aminopyridin-4-yl)-3-(3-fluorophenyl)-1-(1,6-dihydro-6-oxopyridazin-3-yl)-1H-pyrazole obtained in Example 22-4) in place of 4-(2-aminopyridin-4-yl)-1-(1,6-dihydro-6-oxopyridazin-3-yl)-3-phenyl-1H-pyrazole to obtain 207 mg of the title compound as a white powder. (Yield: 69%)

Sources & evidence

ORD record
ord-34e3f61bfaf643cabfe639a4cce01b64
Source dataset
uspto-grants-2007_11
Patent number
US07294625B2

Reaction notes

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