HCID 9973892, compound → HCID 10318782, compound

HRID 1592910Notes

Reaction equation

HRID 1592910 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[C:9]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=3)=[N:10][N:11]([C:13]3[CH:18]=[CH:17][C:16](=[O:19])[NH:15][N:14]=3)[CH:12]=2)[CH:5]=[CH:4][N:3]=1.NC1C=C(C2C(C3C=CC=CC=3)=NN(C3C=CC(=O)NN=3)C=2)C=CN=1>>[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[C:9]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=3)=[N:10][N:11]([C:13]3[CH2:18][CH2:17][C:16](=[O:19])[NH:15][N:14]=3)[CH:12]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 9973892HCID 9973892, compoundHCID 10453457HCID 10453457, compound

Product 1

HCID 10318782HCID 10318782, compoundYield 48.3%

Procedure

The reaction was carried out in the same manner as in Example 49 except for using 797 mg (2.00 mmol) of 4-(2-aminopyridin-4-yl)-1-(1,6-dihydro-6-oxopyridazin-3-yl)-3-(3-trifluoromethylphenyl)-1H-pyrazole obtained in Example 25-4) in place of 4-(2-aminopyridin-4-yl)-1-(1,6-dihydro-6-oxopyridazin-3-yl)-3-phenyl-1H-pyrazole to obtain 387 mg of the title compound as a white powder. (Yield: 48%)

Sources & evidence

ORD record
ord-4e39419c5e6a4ca897c781f9324aa6a6
Source dataset
uspto-grants-2007_11
Patent number
US07294625B2

Reaction notes

Loading…