HCID 9973892, compound → HCID 11743510, compound

HRID 1592912Notes

Reaction equation

HRID 1592912 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[CH:18]=[CH:17][N:16]=[C:15]([NH:19][CH2:20][C:21]([F:24])([F:23])[F:22])[CH:14]=3)=[CH:11][N:10]([C:25]3[CH:30]=[CH:29][C:28](=[O:31])[NH:27][N:26]=3)[N:9]=2)=[CH:4][CH:3]=1.NC1C=C(C2C(C3C=CC=CC=3)=NN(C3C=CC(=O)NN=3)C=2)C=CN=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([C:13]3[CH:18]=[CH:17][N:16]=[C:15]([NH:19][CH2:20][C:21]([F:23])([F:22])[F:24])[CH:14]=3)=[CH:11][N:10]([C:25]3[CH2:30][CH2:29][C:28](=[O:31])[NH:27][N:26]=3)[N:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 9973892HCID 9973892, compoundHCID 10252096HCID 10252096, compound

Product 1

HCID 11743510HCID 11743510, compoundYield 65%

Procedure

The reaction was carried out in the same manner as in Example 49 except for using 200 mg (0.47 mmol) of 3-(4-fluorophenyl)-1-(1,6-dihydro-6-oxopyridazin-3-yl)-4-[2-(2,2,2-trifluoroethyl)aminopyridin-4-yl]-1H-pyrazole obtained in Example 28-2) in place of 4-(2-aminopyridin-4-yl)-1(1,6-dihydro-6-oxopyridazin-3-yl)-3-phenyl-1H-pyrazole to obtain 130 mg of the title compound as a white powder. (Yield: 65%)

Sources & evidence

ORD record
ord-2def7cd41ee8486893fc85bb36298753
Source dataset
uspto-grants-2007_11
Patent number
US07294625B2

Reaction notes

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