HCID 9973892, compound → HCID 10384153, compound

HRID 1592913Notes

Reaction equation

HRID 1592913 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[C:9]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)=[N:10][N:11]([C:13]3[C:18]([CH3:19])=[CH:17][C:16](=[O:20])[NH:15][N:14]=3)[CH:12]=2)[CH:5]=[CH:4][N:3]=1.NC1C=C(C2C(C3C=CC=CC=3)=NN(C3C=CC(=O)NN=3)C=2)C=CN=1>>[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[C:9]([C:21]3[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=3)=[N:10][N:11]([C:13]3[CH:18]([CH3:19])[CH2:17][C:16](=[O:20])[NH:15][N:14]=3)[CH:12]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 9973892HCID 9973892, compoundHCID 10428711HCID 10428711, compound

Product 1

HCID 10384153HCID 10384153, compoundYield 48%

Procedure

The reaction was carried out in the same manner as in Example 49 except for using 100 mg (0.28 mmol) of 4-(2-aminopyridin-4-yl)-3-(4-fluorophenyl)-1-(1,6-dihydro-4-methyl-6-oxopyridazin-3-yl)-1H-pyrazole obtained in Example 31-2) in place of 4-(2-aminopyridin-4-yl)-1-(1,6-dihydro-6-oxopyridazin-3-yl)-3-phenyl-1H-pyrazole to obtain 48.0 mg of the title compound as a white powder. (Yield: 48%)

Sources & evidence

ORD record
ord-b72701bb1bae428d9d7b38a49ab5fad6
Source dataset
uspto-grants-2007_11
Patent number
US07294625B2

Reaction notes

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