HCID 9973892, compound → HCID 11743511, compound

HRID 1592916Notes

Reaction equation

HRID 1592916 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]([C:13]2[CH:18]=[CH:17][N:16]=[C:15]([NH:19][CH2:20][C:21]([F:24])([F:23])[F:22])[CH:14]=2)=[CH:11][N:10]([C:25]2[CH:30]=[CH:29][C:28](=[O:31])[NH:27][N:26]=2)[N:9]=1.NC1C=C(C2C(C3C=CC=CC=3)=NN(C3C=CC(=O)NN=3)C=2)C=CN=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]([C:13]2[CH:18]=[CH:17][N:16]=[C:15]([NH:19][CH2:20][C:21]([F:24])([F:22])[F:23])[CH:14]=2)=[CH:11][N:10]([C:25]2[CH2:30][CH2:29][C:28](=[O:31])[NH:27][N:26]=2)[N:9]=1

Participants

3

Reactant 2

HCID 9973892HCID 9973892, compoundHCID 10365373HCID 10365373, compound

Product 1

HCID 11743511HCID 11743511, compoundYield 64%

Procedure

The reaction was carried out in the same manner as in Example 49 except for using 243 mg (0.57 mmol) of 3-(2-fluorophenyl)-1-(1,6-dihydro-6-oxopyridazin-3-yl)-4-[2-(2,2,2-trifluoroethyl)aminopyridin-4-yl]-1H-pyrazole obtained in Example 34-2) in place of 4-(2-aminopyridin-4-yl)-1-(1,6-dihydro-6-oxopyridazin-3-yl)-3-phenyl-1H-pyrazole to obtain 155 mg of the title compound as a beige powder. (Yield: 64%)

Sources & evidence

ORD record
ord-a78e25d63a164748a7e607d9cf3dd88d
Source dataset
uspto-grants-2007_11
Patent number
US07294625B2

Reaction notes

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