Cyclopropanecarbonyl chloride → HCID 10409767, compound

Participants

Reaction Steps

The reaction was carried out in the same manner as in Example 9 except for using 50.0 mg (0.14 mmol) of 4-(2-aminopyridin-4-yl)-3-(2-fluorophenyl)-1-(1,4,5,6-tetrahydro-6-oxopyridazin-3-yl)-1H-pyrazole obtained in Example 55 in place of 4-(2-aminopyridin-4-yl)-3-(4-fluorophenyl)-1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazole, and using 15.7 mg (0.15 mmol) of cyclopropylcarbonyl chloride in place of acetic anhydride to obtain 41.9 mg of the title compound as a white powder. (Yield: 70%)

Provenance & Evidence