Phosphorus oxychloride → 4-Chloro-6-(3-nitrophenyl)furo[2,3-d]pyrimidine

Participants

Reaction Steps

11 g of 4-hydroxy-6-(3-nitrophenyl)furo[2,3-d]pyrimidine are heated for 4 h to RF in ca. 340 ml of phosphorus oxychloride. Afterwards, the reaction mixture is left to stand over night and then added to 5 kg of drained ice. The resulting suspension is filtered by suction and washed with a lot of H2O. The residue is dried in a HV and sublimated at ca. 200° C.; m.p.: 196-205° C.

Provenance & Evidence