1,4-Dioxane hydrochloride → HCID 86621186, compound

HRID 1592993Notes

Reaction equation

HRID 1592993 reaction equation
[CH2:1]([N:4]([CH2:60][CH2:61][CH3:62])[C:5]([C:7]1[CH:8]=[C:9]([CH:52]=[C:53]([C:55]2[O:56][CH:57]=[CH:58][N:59]=2)[CH:54]=1)[C:10]([O:12][C@H:13]([CH2:32][N:33](C(OC(C)(C)C)=O)[CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[C:37]([C:41]([F:44])([F:43])[F:42])[CH:36]=1)[C@@H:14]([NH:24]C(OC(C)(C)C)=O)[CH2:15][C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[CH:17]=1)=[O:11])=[O:6])[CH2:2][CH3:3].[ClH:63].O1CCOCC1>>[ClH:63].[ClH:63].[CH2:60]([N:4]([CH2:1][CH2:2][CH3:3])[C:5]([C:7]1[CH:8]=[C:9]([CH:52]=[C:53]([C:55]2[O:56][CH:57]=[CH:58][N:59]=2)[CH:54]=1)[C:10]([O:12][C@H:13]([CH2:32][NH:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[C:37]([C:41]([F:43])([F:44])[F:42])[CH:36]=1)[C@@H:14]([NH2:24])[CH2:15][C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[CH:17]=1)=[O:11])=[O:6])[CH2:61][CH3:62]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 69322925HCID 69322925, compound

Product 1

HCID 86621186HCID 86621186, compound

Procedure

(1R,2S)-2-[(tert-butoxycarbonyl)amino]-1-({(tert-butoxycarbonyl)[3-(trifluoromethyl)benzyl]amino}methyl)-3-(3,5-difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate (482 mg, 0.55 mmole) is dissolved in hydrochloric acid/dioxane (4N, 3 ml) is stirred for 1 hour at 20-25°. The solvent is then removed under reduced pressure to give the title compound, MS (MH+) 673.

Workup

  1. customThe solvent is then removed under reduced pressure

Sources & evidence

ORD record
ord-ebd30a2f9143426d85fbccaa3e148371
Source dataset
uspto-grants-2007_11
Patent number
US07294642B2

Reaction notes

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