HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1592995Generated: October 29, 2026
Sodium Carbonate → N-(1-benzylpiperidin-4-yl)-2-nitro-4-methylsulphonylaniline
https://huagongshe.com/reaction/1592995
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-Fluoro-4-methanesulfonyl-2-nitrobenzene | HCID 313137 | — |
| Reactant | 1-Benzyl-4-piperidylamine | HCID 415852 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N-(1-benzylpiperidin-4-yl)-2-nitro-4-methylsulphonylaniline | HCID 9281505 | 98.5% |
Reaction Steps
4-Amino-1-benzylpiperidine (87 g) was added slowly during 20 minutes to a stirred mixture of 2-fluoro-5-methylsulphonyl-nitrobenzene (100 g) and anhydrous sodium carbonate (35 g) in 500 mL DMSO, the internal temperature rose from 20° C. to 50° C. The mixture was stirred at 90° C. for 12 hours, then poured into ice/water and the yellow solid was filtered off, redissolved in dichloromethane, dried and evaporated to give 175 g N-(1-benzylpiperidin-4-yl)-2-nitro-4-methylsulphonylaniline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07294636B2 |
|---|
| Source dataset | uspto-grants-2007_11 |
|---|
| ORD ID | ord-cdb0c86b30f8408d9f59b887e5cbf963 |
|---|
| Source note | uspto-grants-2007_11 |
|---|
