HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 1-(1-benzylpiperidin-4-yl)-5-methylsulphonyl-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | N-(1-benzylpiperidin-4-yl)-2-amino-4-methylsulphonylaniline | HCID 68704672 | — |
| Solvent | Trimethyl orthoformate | HCID 9005 | — |
| Product | 1-(1-benzylpiperidin-4-yl)-5-methylsulphonyl-1H-benzimidazole | HCID 68709204 | 629.2% |
Reaction Steps
The crude material from step 2 (130 g) was stirred in 300 mL trimethylorthoformate containing 4-toluenesulphonic acid (8 g) at 90° C. for one hour, and collecting the methanol distillate. The reaction was cooled and filtered to give 108 g 1-(1-benzylpiperidin-4-yl)-5-methylsulphonyl-1H-benzimidazole as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07294636B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-5e414ce351a742f7b04d66de323a4bcc |
| Source note | uspto-grants-2007_11 |