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1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid → 4-(3-Benzyl-[1,2,4]oxadiazol-5-yl)-piperidine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid | HCID 392871 | — |
| 反応物 | N'-hydroxy-2-phenylethanimidamide | HCID 2731007 | — |
| 反応物 | 4-{3-[4-(Methylthio)benzyl]-1,2,4-oxadiazol-5-yl}piperidine hydrochloride | HCID 68709132 | — |
| 生成物 | 4-(3-Benzyl-[1,2,4]oxadiazol-5-yl)-piperidine hydrochloride | HCID 68707330 | — |
反応手順
This was prepared from N′-hydroxy-2-phenylethanimidamide and 1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid using a similar method to that used to prepare 4-{3-[4-(methylthio)benzyl]-1,2,4-oxadiazol-5-yl}piperidine hydrochloride (Method E, Steps 1, 2); NMR: 1.96 (2H, m), 2.15(2H, dd), 3.01(2H, t), 3.24 (2H, dd), 3.40 (1H, m), 4.09 (2H, s), 7.25 (5H, m), 9.31(2H, br s); MS: 244 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07294636B2 |
| 出典データセット | uspto-grants-2007_11 |
| ORD ID | ord-f2899366c5f24882966ea61fb6ed9126 |
| 出典メモ | uspto-grants-2007_11 |