4-(Methylsulfonyl)benzyl Bromide → HCID 58797590, compound

HRID 1593008Notes

Reaction equation

HRID 1593008 reaction equation
[CH3:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9]Br)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[N:13]1[NH:14][N:15]=[N:16][C:17]=1[CH:18]1[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]1.ClC1C=CC(CN2N=NC(C3CCNCC3)=N2)=CC=1>>[CH3:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9][N:14]2[N:15]=[N:16][C:17]([CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)=[N:13]2)=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

4

Reactant 3

HCID 27335814-(Methylsulfonyl)benzyl BromideHCID 18187701Tert-butyl 4-(2H-tetrazol-5-YL)piperidine-1-carboxylateHCID 58797593HCID 58797593, compound

Product 1

HCID 58797590HCID 58797590, compound

Procedure

This was prepared from 4-methanesulphonylbenzyl bromide and tert-butyl 4-(2H-tetrazol-5-yl)piperidine-1-carboxylate using a similar method to that used to prepare 4-[2-(4-chloro-benzyl)-2H-tetrazol-5-yl]-piperidine (Method G, Steps 4 and 5); NMR (CDCl3): 1.8 (m, 2H), 2.05 (m, 2H), 2.8 (m, 2H), 3.05 (s, 3H), 3.1 (m, 1H), 3.2 (m, 2H), 5.89 (s, 2H), 7.55 (d, 2H), 7.95 (d, 2H).

Sources & evidence

ORD record
ord-87564830a2fd431892235545d6e9fa6f
Source dataset
uspto-grants-2007_11
Patent number
US07294636B2

Reaction notes

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