HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Sulfonylurea → N-({[4-(6-amino-7-fluoro-1-oxoisoquinolin-2(1H)-yl)phenyl]amino}carbonyl)-4-chlorothiophene-2-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Sulfonylurea | HCID 11819083 | — |
| Reactant | 4-Chlorothiophene-2-sulfonamide | HCID 22019465 | — |
| Reactant | [2-(4-Amino-phenyl)-7-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl]-methyl-carbamic acid tert-butyl ester | HCID 58998471 | — |
| Product | N-({[4-(6-amino-7-fluoro-1-oxoisoquinolin-2(1H)-yl)phenyl]amino}carbonyl)-4-chlorothiophene-2-sulfonamide | HCID 69146400 | — |
Reaction Steps
An analogous sulfonylurea coupling and de-protection procedure to that described in Example 29 was performed on [2-(4-Amino-phenyl)-7-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl]-methyl-carbamic acid tert-butyl ester (Example 9) and 4-chlorothiophene-2-sulfonamide to give N-({[4-(6-amino-7-fluoro-1-oxoisoquinolin-2(1H)-yl)phenyl]amino}carbonyl)-4-chlorothiophene-2-sulfonamide. ES-MS (M+H)+=507.0, 509.0 (Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07294635B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-184be4e898094bdda085a72641fbaaf4 |
| Source note | uspto-grants-2007_11 |