1-Sulfonylurea → HCID 69144758, compound

Participants

Reaction Steps

An analogous sulfonylurea coupling and de-protection procedure to that described in Example 29 was performed on [2-(4-Amino-phenyl)-7-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl]-methyl-carbamic acid tert-butyl ester (Example 9) and 4-difluoromethylthiophene-2-sulfonamide to give N-({[4-(6-amino-7-fluoro-1-oxoisoquinolin-2(1H)-yl)phenyl]amino}carbonyl)-4-difluoromethylthiophene-2-sulfonamide. ES-MS (M+H)+=523.1; 1H-NMR (DMSO-d6) δ (ppm): 9.24-9.16 (bs, 1H), 8.34-8.28 (m, 1H), 7.88-7.84 (m, 1H), 7.66-7.60 (d, J=12.4 Hz, 1H), 7.48-7.42 (d, J=8.8 Hz, 2H), 7.34-7.26 (d, J=8.8 Hz, 2H), 7.25-7.20 (d, J=7.3 Hz, 1H), 7.19-6.91 (t, J=55.3 Hz, 1H), 6.72-6.66 (d, 8.4 Hz, 1H), 6.58-6.48 (bs, 1H), 6.50-6.46 (d, J=7.3 Hz, 1H), 2.82-2.77 (s, 3H).

Provenance & Evidence