Benzenesulfonamide → HCID 69145341, compound

Participants

Reaction Steps

An analogous sulfonylurea coupling and de-protection procedure to that described in Example 29 was performed on [2-(4-Amino-phenyl)-7-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl]-methyl-carbamic acid tert-butyl ester (Example 9) and benzenesulfonamide to give N-({[4-(6-amino-7-fluoro-1-oxoisoquinolin-2(1H)-yl)phenyl]amino}carbonyl)-benzenesulfonamide. ES-MS (M+H)+=467.1; 1H-NMP (ΔMΣO-66) δ (ppm): 9.13-9.06 (bs, 1H), 7.98-7.92 (d, J=8.4 Hz, 2H), 7.70-7.56 (m, 4H), 7.44-7.37 (d, J=8.8 Hz, 2H), 7.39-7.24 (d, J=8.8 Hz, 2H), 7.21-7.18 (d, J=7.3 Hz, 1H), 6.74-6.66 (d, J=8.4 Hz, 1H), 6.56-6.48 (bs, 1H), 6.49-6.46 (d, J=7.7 Hz, 1H), 2.82-2.76 (bd, J=4.4 Hz, 3H).

Provenance & Evidence