Carbon tetrabromide → 2-(Bromomethyl)-1-fluoro-4-nitrobenzene

Participants

Reaction Steps

To a solution of 2-fluoro-5-nitrobenzyl alcohol (1 g, 5.84 mmol) in 25 mL ether, was added tetrabromomethane (3.87 g, 11.7 mmol), followed by triphenylphosphine (3.39 g, 11.7 mmol). The mixture was stirred at room temperature for 2 hours. The reaction was concentrated and the crude residue purified by column chromatography (silica, 10% EtOAc/hexane) to give pure 2-bromomethyl-1-fluoro-4-nitro-benzene.

Provenance & Evidence