Sodium borohydride → HCID 58998410, compound

Participants

Reaction Steps

This analog compound was obtained from reduction of N-[({3-acetyl-4-[7-fluoro-6-(methylamino)-1-oxoisoquinolin-2(1H)-yl]phenyl}amino)carbonyl]-5-chlorothiophene-2-sulfonamide of Example 70. To a solution of N-[({3-acetyl-4-[7-fluoro-6-(methylamino)-1-oxoisoquinolin-2(1H)-yl]phenyl}amino)carbonyl]-5-chlorothiophene-2-sulfonamide (18 mg, 0.033 mmol) in 2 mL ethanol, was added sodium borohydride (20 mg, 0.53 mmol). The mixture was stirred at room temperature for 30 minutes. Workup and purification provided 5-chloro-N-({[4-[7-fluoro-6-(methylamino)-1-oxoisoquinolin-2(1H)-yl]-3-(1-hydroxyethyl)phenyl]amino}carbonyl)thiophene-2-sulfonamide as a mixture of rotamers. ES-MS (M+H)+=551, 553(Cl).

Provenance & Evidence