2,2,2-Trifluoroethanol → HCID 54370116, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of trifluoroethanol in 4 mL dry THF, was added tert-butoxide (378 mg, 3.37 mmol) at 0° C. The resulting mixture was added dropwise to the solution of 2,4-difluoro-1-nitro-benzene (536 mg, 3.37 mmol) in 5 mL dry THF at 0° C. The mixture was stirred at 0° C. for 30 minutes, then diluted with ethyl acetate and washed with brine. The organic layers were combined and concentrated in vacuo to give 4-fluoro-1-nitro-2-(2,2,2-trifluoro-ethoxy)-benzene.

Provenance & Evidence