Bromine → HCID 21102188, compound

HRID 1593077Notes

Reaction equation

HRID 1593077 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:5]=1[NH2:11])([CH3:3])[CH3:2].[Br:12]Br>C(O)(=O)C>[Br:12][C:8]1[CH:7]=[C:6]([CH3:10])[C:5]([NH2:11])=[C:4]([CH:1]([CH3:3])[CH3:2])[CH:9]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 789206-Isopropyl-o-toluidine

Product 1

HCID 21102188HCID 21102188, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of 2-isopropyl-6-methyl-phenylamine (1 ml, 6.4 mmol) in 6.5 mL acetic acid, was added bromine (0.33 ml, 6.4 mmol) dropwise over 10 minutes at room temperature. The mixture was stirred at room temperature under argon for 20 minutes. A precipitate was formed and collected by filtration and washed with ether to give pure 4-bromo-2-isopropyl-6-methyl-phenyl amine.

Workup

  1. customA precipitate was formed
  2. filtrationcollected by filtration
  3. washwashed with ether

Sources & evidence

ORD record
ord-98cb325bea984d5c8562c90899befd84
Source dataset
uspto-grants-2007_11
Patent number
US07294635B2

Reaction notes

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