HCID 58998406, compound → HCID 58998399, compound

Participants

Reaction Steps

A mixture of tert-butyl 7-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl(methyl)carbamate (Example 45, 700 mg, 2.40 mmol) and PtO2 (470 mg) in MeOH (30 mL) containing concentrated HCl (8 drops) was hydrogenated under 300 psi in a high pressure vessel overnight. The reaction mixture was then filtered and the filtrate was concentrated in vacuo. The residue was treated with TFA (10 mL) and stirred for 1 hr, after which, the TFA solution was concentrated in vacuo. The residue was purified by RP-HPLC to give the noted intermediate compound (142 mg). ES-MS (M+H)+=195.

Provenance & Evidence