Ethyl ((5-chlorothiophen-2-yl)sulfonyl)carbamate → HCID 58998465, compound

Participants

Reaction Steps

To a solution of 2-(4-aminophenyl)-7-fluoro-6-(methylamino)-3,4-dihydroisoquinolin-1(2H)-one (62 mg, 0.22 mmol) in HOAc (4 mL) at 100 C, ethyl 5-chlorothiophen-2-ylsulfonylcarbamate (119 mg, 0.44 mmol) was added. After being stirred at room temperature for 1 h, the reaction mixture was concentrated in vacuo. The residue was purified by RP-HPLC to give the titled compound as a powder (25 mg). ES-MS (M+H)+=509, 511 (Cl pattern).

Provenance & Evidence