Selectfluor → HCID 58998495, compound

Participants

Reaction Steps

To a solution of 1-(5-chlorothiophen-2-ylsulfonyl)-3-(4-(7-fluoro-6-(methylamino)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)phenyl)urea (17 mg, 0.033 mmol) in DMF (2 mL) at room temperature, selectFluor (1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octanebis(tetrafluoroborate), 32 mg, 0.090 mmol) was added. After being stirred at room temperature for 1 h, the reaction mixture was concentrated in vacuo. The residue was purified by RP-HPLC to give the titled compound as a powder (1 mg). ES-MS (M+H)+=527, 529 (Cl pattern).

Provenance & Evidence