HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methyl acetoacetate → 5-(3,5-Bis-trifluoromethyl-phenyl)-1-(3-fluoro-benzyl)-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methyl acetoacetate | HCID 7757 | — |
| Edukt | Cyclohexylamine | HCID 7965 | — |
| Edukt | 3-Fluorobenzylamine | HCID 66853 | — |
| Edukt | 3,5-Bis(trifluoromethyl)phenacyl bromide | HCID 2736170 | — |
| Produkt | 5-(3,5-Bis-trifluoromethyl-phenyl)-1-(3-fluoro-benzyl)-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide | HCID 58998963 | — |
Reaktionsschritte
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 1-(3,5-bis-trifluoromethyl-phenyl)-2-bromo-ethanone as compound of formula S, 3-fluorobenzylamine as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 527.2 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07294644B2 |
| Quelldatensatz | uspto-grants-2007_11 |
| ORD ID | ord-5a4993b4a59349c4968187f1eac11b2f |
| Quellennotiz | uspto-grants-2007_11 |