化工社化工社 化学情報印刷レポート · 研究参考用
Methyl acetoacetate → 5-(3,5-Bis-trifluoromethyl-phenyl)-1-(3-fluoro-benzyl)-2-methyl-1H-pyrrole-3-carboxylic acid piperidin-1-ylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl acetoacetate | HCID 7757 | — |
| 反応物 | 1-Aminopiperidine | HCID 16658 | — |
| 反応物 | 3-Fluorobenzylamine | HCID 66853 | — |
| 反応物 | 3,5-Bis(trifluoromethyl)phenacyl bromide | HCID 2736170 | — |
| 生成物 | 5-(3,5-Bis-trifluoromethyl-phenyl)-1-(3-fluoro-benzyl)-2-methyl-1H-pyrrole-3-carboxylic acid piperidin-1-ylamide | HCID 58999011 | — |
反応手順
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 1-(3,5-bis-trifluoromethyl-phenyl)-2-bromo-ethanone as compound of formula S, 3-fluorobenzylamine as R3—(CH2)m—NH2 and 1-piperidinamine as R1R2NH, MS (ISP) 528.2 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07294644B2 |
| 出典データセット | uspto-grants-2007_11 |
| ORD ID | ord-b201bdcef19d426ca6371caf06a695e8 |
| 出典メモ | uspto-grants-2007_11 |