Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl acetoacetate → (r)-5-(3,5-Bis-trifluoromethyl-phenyl)-1-(3-fluoro-benzyl)-2-methyl-1h-pyrrole-3-carboxylic acid sec-butylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl acetoacetate | HCID 7757 | — |
| 반응물 | 3-Fluorobenzylamine | HCID 66853 | — |
| 반응물 | (R)-sec-butylamine | HCID 2724537 | — |
| 반응물 | 3,5-Bis(trifluoromethyl)phenacyl bromide | HCID 2736170 | — |
| 생성물 | (r)-5-(3,5-Bis-trifluoromethyl-phenyl)-1-(3-fluoro-benzyl)-2-methyl-1h-pyrrole-3-carboxylic acid sec-butylamide | HCID 58999076 | — |
반응 단계
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 1-(3,5-bis-trifluoromethyl-phenyl)-2-bromo-ethanone as compound of formula S, 3-fluorobenzylamine as R3—(CH2)m—NH2 and (R)-sec-butylamine as R1R2NH, MS (ISP) 501.2 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07294644B2 |
| 출처 데이터셋 | uspto-grants-2007_11 |
| ORD ID | ord-1c428d04cb30408e905d7e51eee89ab9 |
| 출처 메모 | uspto-grants-2007_11 |