HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → (s)-5-(3,5-Bis-trifluoromethyl-phenyl)-1-cyclopropylmethyl-2-methyl-1h-pyrrole-3-carboxylic acid sec-butylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Cyclopropanemethanamine | HCID 75646 | — |
| Reactant | 3,5-Bis(trifluoromethyl)phenacyl bromide | HCID 2736170 | — |
| Reactant | 2-Butanamine, (S)- | HCID 6713753 | — |
| Product | (s)-5-(3,5-Bis-trifluoromethyl-phenyl)-1-cyclopropylmethyl-2-methyl-1h-pyrrole-3-carboxylic acid sec-butylamide | HCID 58999102 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 1-(3,5-Bis-trifluoromethyl-phenyl)-2-bromo-ethanone as compound of formula S, cyclopropanemethylamine as R3—(CH2)m—NH2 and (S)-sec-butylamine as R1R2NH, MS (ISP) 447.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07294644B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-b866a82195494e8bbbde42fa5411dd4e |
| Source note | uspto-grants-2007_11 |