3,3,3-Trifluoropropylamine → HCID 58999018, compound

HRID 1593167Notes

Reaction equation

HRID 1593167 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:6]=1[O:12][CH3:13])=O.[CH:14]1([CH2:17][NH2:18])[CH2:16][CH2:15]1.[F:19][C:20]([F:25])([F:24])[CH2:21][CH2:22][NH2:23]>>[F:19][C:20]([F:25])([F:24])[CH2:21][CH2:22][NH:23][C:6]([C:5]1[CH:2]=[C:3]([C:5]2[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:6]=2[O:12][CH3:13])[N:18]([CH2:17][CH:14]2[CH2:16][CH2:15]2)[C:3]=1[CH3:2])=[O:12]

Participants

4

Reactant 3

HCID 100013,3,3-TrifluoropropylamineHCID 75646CyclopropanemethanamineHCID 27569852-Bromo-1-(5-fluoro-2-methoxyphenyl)ethanone

Product 1

HCID 58999018HCID 58999018, compound

Procedure

The title compound was synthesized in analogy to Example 68, using 5-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(5-fluoro-2-methoxy-phenyl)-ethanone as compound of formula S, cyclopropanemethylamine as R3—(CH2)m—NH2 and 3,3,3-trifluoro-N-propylamine as R1R2NH, MS (ISP) 399.4 (M+H)+.

Sources & evidence

ORD record
ord-d45799d837084aebaa9e3620258a820c
Source dataset
uspto-grants-2007_11
Patent number
US07294644B2

Reaction notes

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