Methyl acetoacetate → HCID 58998959, compound

HRID 1593175Notes

Reaction equation

HRID 1593175 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5](=O)[CH3:6].Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[C:14]=1[F:23])=O.[CH:24]1([CH2:27][NH2:28])[CH2:26][CH2:25]1.[CH:29]1([NH2:35])[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1>>[CH:29]1([NH:35][C:3]([C:4]2[CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[C:14]=3[F:23])[N:28]([CH2:27][CH:24]3[CH2:26][CH2:25]3)[C:5]=2[CH3:6])=[O:2])[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1

Participants

5

Reactant 4

HCID 7757Methyl acetoacetateHCID 7965CyclohexylamineHCID 75646CyclopropanemethanamineHCID 2778779HCID 2778779, compound

Product 1

HCID 58998959HCID 58998959, compound

Procedure

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2-fluoro-3-trifluoromethyl-phenyl)-ethanone as compound of formula S, cyclopropanemethylamine as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 423.4 (M+H)+.

Sources & evidence

ORD record
ord-44a3544453c245c8a429bb85e59632ba
Source dataset
uspto-grants-2007_11
Patent number
US07294644B2

Reaction notes

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