HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → 1-(2-Hydroxy-cyclohexylmethyl)-2-methyl-5-(2-trifluoromethoxy-phenyl)-1H-pyrrole-3-carboxylic acid cyclohexylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | 2-(Aminomethyl)cyclohexan-1-ol | HCID 533885 | — |
| Reactant | 2-(Trifluoromethoxy)phenacyl bromide | HCID 2778684 | — |
| Product | 1-(2-Hydroxy-cyclohexylmethyl)-2-methyl-5-(2-trifluoromethoxy-phenyl)-1H-pyrrole-3-carboxylic acid cyclohexylamide | HCID 58998922 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2-trifluoromethoxy-phenyl)-ethanone as compound of formula S, 2-aminomethyl-1-cyclohexanol as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 479.6 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07294644B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-d45115ea0d30452c911d9e274f377d69 |
| Source note | uspto-grants-2007_11 |