化工社化工社 化学情報印刷レポート · 研究参考用
Methyl acetoacetate → 5-(2,5-Bis-trifluoromethyl-phenyl)-1-cyclopropylmethyl-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl acetoacetate | HCID 7757 | — |
| 反応物 | Cyclohexylamine | HCID 7965 | — |
| 反応物 | Cyclopropanemethanamine | HCID 75646 | — |
| 反応物 | 1-(2,5-Bis-trifluoromethyl-phenyl)-2-bromo-ethanone | HCID 22137987 | — |
| 生成物 | 5-(2,5-Bis-trifluoromethyl-phenyl)-1-cyclopropylmethyl-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide | HCID 58998949 | — |
反応手順
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 1-(2,5-bis-trifluoromethyl-phenyl)-2-bromo-ethanone as compound of formula S, cyclopropanemethylamine as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 473.1(M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07294644B2 |
| 出典データセット | uspto-grants-2007_11 |
| ORD ID | ord-c9cf8839558b459c84a0c79f29900c09 |
| 出典メモ | uspto-grants-2007_11 |