HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methyl acetoacetate → 5-(2-Fluoro-5-trifluoromethyl-phenyl)-1-((SR,2RS)-2-hydroxy-cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methyl acetoacetate | HCID 7757 | — |
| Edukt | Cyclohexylamine | HCID 7965 | — |
| Edukt | 2-Fluoro-5-(trifluoromethyl)phenacyl bromide | HCID 2778784 | — |
| Edukt | cis-2-Aminomethyl-1-cyclohexanol | HCID 12483365 | — |
| Produkt | 5-(2-Fluoro-5-trifluoromethyl-phenyl)-1-((SR,2RS)-2-hydroxy-cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide | HCID 10345085 | — |
Reaktionsschritte
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2-fluoro-5-trifluoromethyl-phenyl)-ethanone as compound of formula S, cis-2-aminomethyl-1-cyclohexanol as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 480.2 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07294644B2 |
| Quelldatensatz | uspto-grants-2007_11 |
| ORD ID | ord-0b0aa2738f014dcdbdc60466c499b9cc |
| Quellennotiz | uspto-grants-2007_11 |