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HRID1593191

反应详情

EQUATION

反应方程式

HRID 1593191 的结构方程式

REACTANTS

反应物

5
结构：COC(=O)CC(C)=O
HCID7757

Methyl acetoacetate

C5H8O3

结构：N[C@@H]1CCCC[C@H]1O
HCID735777

(1R,2R)-2-Aminocyclohexanol

C6H13NO

结构：CC1(C)C[C@@H]1C(N)=O
HCID10197657

(+)-2,2-Dimethylcyclopropanecarboxamide

C6H11NO

结构：[Al+3].[H-].[H-].[H-].[H-].[Li+]
HCID21226445

未命名化合物

结构：O=C(CBr)c1cc(Cl)ccc1F
HCID79021921

未命名化合物

PRODUCTS

生成物

1
结构：Cc1c(C(=O)N[C@@H]2CCCC[C@H]2O)cc(-c2cc(Cl)ccc2F)n1C[C@H]1CC1(C)C
HCID58998912

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(5-chloro-2-fluoro-phenyl)-ethanone as compound of formula S, C—(S)-(2,2-dimethyl-cyclopropyl)-methylamine (prepared from (S)-2,2-dimethyl-cyclopropanecarboxylic acid amide by reduction with LiAlH4 according to the procedure described by Saski et al. J. Org. Chem. 1971, 36, 1968-1971) as R3—(CH2)m—NH2 and (1R,2R)-2-amino-cyclohexanol as R1R2NH, MS (ISP) 433.4 (M+H)+.