Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl acetoacetate → 5-(2-Chloro-5-trifluoromethyl-phenyl)-1-((1RS,2RS)-2-hydroxy-cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl acetoacetate | HCID 7757 | — |
| 반응물 | Cyclohexylamine | HCID 7965 | — |
| 반응물 | trans-2-Aminomethyl-1-cyclohexanol | HCID 2724658 | — |
| 반응물 | 2-Chloro-5-(trifluoromethyl)phenacyl bromide | HCID 2783183 | — |
| 생성물 | 5-(2-Chloro-5-trifluoromethyl-phenyl)-1-((1RS,2RS)-2-hydroxy-cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide | HCID 10074576 | — |
반응 단계
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2-chloro-5-trifluoromethyl-phenyl)-ethanone as compound of formula S, trans-2-aminomethyl-1-cyclohexanol as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 497.4 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07294644B2 |
| 출처 데이터셋 | uspto-grants-2007_11 |
| ORD ID | ord-836fee0da9244954a14fa44cee4e5b63 |
| 출처 메모 | uspto-grants-2007_11 |