Hydrochloric Acid → Cinacalcet Hydrochloride

Participants

Reaction Steps

Cinacalcet base (2.0 g) prepared according to Example 1 was dissolved in acetone (4 ml) at room temperature. Then 1N HCl (1.5 eq.) and water (40 ml) were added. The mixture was stirred at room temperature for 4 hours to obtain a precipitate. The product was isolated by filtration, washed with water (10 ml) and dried at 50° C. in a vacuum oven for 24 hours to obtain 1.75 g of cinacalcet hydrochloride containing less than 0.15 area percent of CNC-carbamate as measured by HPLC. (purity by HPLC 99.9 percent).

Provenance & Evidence