2(4-Tolylsulfonyl)ethyl 4-(4-methoxy-2-nitro-phenyl)aminosulfonyl-2-(2-[4-tolylsulfonyl]ethoxycarbonylmethoxy)phenoxyacetate → 2(4-Tolylsulfonyl)ethyl 4-(2-amino-4-methoxy-phenyl)aminosulfonyl-2-(2-[4-tolylsulfonyl]ethoxycarbonylmethoxy)phenoxyacetate

HRID 1593238Notes

Reaction equation

HRID 1593238 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][S:10]([C:13]2[CH:35]=[CH:34][C:16]([O:17][CH2:18][C:19]([O:21][CH2:22][CH2:23][S:24]([C:27]3[CH:32]=[CH:31][C:30]([CH3:33])=[CH:29][CH:28]=3)(=[O:26])=[O:25])=[O:20])=[C:15]([O:36][CH2:37][C:38]([O:40][CH2:41][CH2:42][S:43]([C:46]3[CH:51]=[CH:50][C:49]([CH3:52])=[CH:48][CH:47]=3)(=[O:45])=[O:44])=[O:39])[CH:14]=2)(=[O:12])=[O:11])=[C:5]([N+:53]([O-])=O)[CH:4]=1>[Pt]=O>[NH2:53][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[CH:7][C:6]=1[NH:9][S:10]([C:13]1[CH:35]=[CH:34][C:16]([O:17][CH2:18][C:19]([O:21][CH2:22][CH2:23][S:24]([C:27]2[CH:28]=[CH:29][C:30]([CH3:33])=[CH:31][CH:32]=2)(=[O:25])=[O:26])=[O:20])=[C:15]([O:36][CH2:37][C:38]([O:40][CH2:41][CH2:42][S:43]([C:46]2[CH:51]=[CH:50][C:49]([CH3:52])=[CH:48][CH:47]=2)(=[O:44])=[O:45])=[O:39])[CH:14]=1)(=[O:11])=[O:12]

Participants

3

Reactant 1

HCID 224793242(4-Tolylsulfonyl)ethyl 4-(4-methoxy-2-nitro-phenyl)aminosulfonyl-2-(2-[4-tolylsulfonyl]ethoxycarbonylmethoxy)phenoxyacetate

Product 1

HCID 224793432(4-Tolylsulfonyl)ethyl 4-(2-amino-4-methoxy-phenyl)aminosulfonyl-2-(2-[4-tolylsulfonyl]ethoxycarbonylmethoxy)phenoxyacetate

Reagents, catalysts & solvents 1

HCID 82844Platinum oxide (PtO)Catalyst

Procedure

2(4-Tolylsulfonyl)ethyl 4-(4-methoxy-2-nitro-phenyl)aminosulfonyl-2-(2-[4-tolylsulfonyl]ethoxycarbonylmethoxy)phenoxyacetate (Intermediate A17, 6.6 g, 0.0080 mol) was hydrogenated using platinum oxide as catalyst. The mixture was filtered and concentrated. After drying at high vacuum, the residual product, title compound, weighed 5.9 g (93%).

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated
  3. customAfter drying at high vacuum

Sources & evidence

ORD record
ord-5e6087222d8841e3bd559dd428ad9532
Source dataset
uspto-grants-2007_11
Patent number
US07294716B2

Reaction notes

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