反应详情

温度

0 °C

2-Carbamoylmethoxyphenoxyacetamide (Intermediate A84, 112 g, 0.50 mol) was added portion-wise over 15 min to rapidly stirred chlorosulfonic acid (582.5 g, 5.0 mol) cooled to 0° C. Dichloromethane (120 mL) was then added, and the mixture was heated in a 60°-70° C. bath for 3 hr. The mixture was slowly poured into 1.5 Kg of crushed ice, and then water (500 mL) was added. The resulting solid was collected, washed with water (3×500 mL) and acetone (3×500 mL), resuspended in acetone (1 L), again collected, washed with acetone (500 mL), and air dried to yield 125 g (77%) of the title compound.

1. temperaturethe mixture was heated in a 60°-70° C. bath for 3 hr
2. customThe resulting solid was collected
3. washwashed with water (3×500 mL) and acetone (3×500 mL)
4. customagain collected
5. washwashed with acetone (500 mL), and air
6. customdried